{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-167962","form_type":"8-K","ticker":"ANNX","cik":"0001528115","company_name":"Annexon, Inc.","filed_at":"2024-06-25T23:59:59+00:00","discovered_at":"2026-05-14T18:03:18.849110+00:00","generated_at":"2026-06-01T02:10:34.511675+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Annexon Phase 3 trial of ANX005 meets primary endpoint; GBS patients recover faster","bullets":["Primary endpoint at Week 8: 2.41-fold higher likelihood of better health state (p=0.0058).","ANX005 patients walked 31 days earlier and came off ventilation 28 days earlier vs placebo.","At Week 26, 21.5% of ANX005 patients fully recovered (GBS-DS=0) vs 8.6% on placebo (OR 4.14, p=0.0092).","Subgroup with North American/European baseline characteristics showed 3x greater likelihood of better health state at Week 8.","Single infusion generally well-tolerated; safety profile similar to placebo, no increased infections."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-167962","json":"https://secwatch.observer/filing/0001193125-24-167962.json","markdown":"https://secwatch.observer/filing/0001193125-24-167962.md","text":"https://secwatch.observer/filing/0001193125-24-167962.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1528115/000119312524167962/0001193125-24-167962-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1528115/000119312524167962/d822308d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-01T02:10:34.511675+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}