{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-168597","form_type":"8-K","ticker":"LYEL","cik":"0001806952","company_name":"Lyell Immunopharma, Inc.","filed_at":"2024-06-26T23:59:59+00:00","discovered_at":"2026-05-14T18:03:20.228124+00:00","generated_at":"2026-06-01T01:47:19.924261+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Lyell reports 40% ORR in TNBC from Phase 1 LYL797; expands into ovarian cancer","bullets":["ORR of 40% and CBR of 60% at 150e6 CAR T dose in relapsed/refractory TNBC (n=5).","No dose-limiting toxicities in patients without lung involvement; pneumonitis managed with prophylactic steroids.","CAR T cells enhanced with anti-exhaustion technology showed expansion, infiltration, and persistence in solid tumors.","Trial expanded to ROR1+ ovarian/endometrial cancer; new trial for multiple myeloma/CLL planned.","IND submitted for LYL119, next-gen ROR1 CAR T candidate; expected to enter clinic this year."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-168597","json":"https://secwatch.observer/filing/0001193125-24-168597.json","markdown":"https://secwatch.observer/filing/0001193125-24-168597.md","text":"https://secwatch.observer/filing/0001193125-24-168597.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1806952/000119312524168597/0001193125-24-168597-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1806952/000119312524168597/d808272d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-01T01:47:19.924261+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}