{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-175867","form_type":"8-K","ticker":"IDYA","cik":"0001676725","company_name":"IDEAYA Biosciences, Inc.","filed_at":"2024-07-08T23:59:59+00:00","discovered_at":"2026-05-14T18:03:14.071083+00:00","generated_at":"2026-05-31T23:05:46.334481+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"IDEAYA reports 39% ORR in IDE397 Phase 2 monotherapy for MTAP-deletion cancers","bullets":["Overall response rate 39% (1 CR, 6 PRs by RECIST 1.1) in 18 evaluable MTAP-deletion urothelial cancer and NSCLC patients.","Disease control rate 94%; tumor shrinkage observed in 14/18 evaluable patients; 5 of 7 responses still ongoing.","81% ctDNA molecular response rate (13/16 reportable patients with ≥50% ctDNA reduction).","Favorable safety: 5.6% Grade 3+ drug-related AE (1 asthenia); no drug-related discontinuations.","No FDA-approved therapies for MTAP-deletion solid tumors; IDE397 30 mg QD tablet enables long-term dosing."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-175867","json":"https://secwatch.observer/filing/0001193125-24-175867.json","markdown":"https://secwatch.observer/filing/0001193125-24-175867.md","text":"https://secwatch.observer/filing/0001193125-24-175867.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1676725/000119312524175867/0001193125-24-175867-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1676725/000119312524175867/d587447d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T23:05:46.334481+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}