{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-200272","form_type":"8-K","ticker":"VCNX","cik":"0001205922","company_name":"VACCINEX, INC.","filed_at":"2024-08-14T23:59:59+00:00","discovered_at":"2026-05-14T18:03:12.362701+00:00","generated_at":"2026-05-31T09:15:48.736301+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Vaccinex reports pepinemab slows cognitive decline in MCI due to AD; plans partnership","bullets":["Pepinemab showed significant reduction in brain metabolic decline (FDG-PET) in medial temporal cortex (p=0.0297) vs placebo.","In MCI patients, reduced astrocyte reactivity (GFAP) and neuronal damage marker p-tau217; no effect in early dementia.","Cognitive decline slowed in MCI per iADRS and ADAS-Cog13; no benefit in early dementia group.","Company plans to pursue a development partnership to reduce operating expenses going forward.","Pepinemab was well-tolerated, consistent with prior Huntington's disease studies."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-200272","json":"https://secwatch.observer/filing/0001193125-24-200272.json","markdown":"https://secwatch.observer/filing/0001193125-24-200272.md","text":"https://secwatch.observer/filing/0001193125-24-200272.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1205922/000119312524200272/0001193125-24-200272-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1205922/000119312524200272/d838109d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T09:15:48.736301+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}