{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-216320","form_type":"8-K","ticker":"CNTA","cik":"0001847903","company_name":"Centessa Pharmaceuticals plc","filed_at":"2024-09-10T23:59:59+00:00","discovered_at":"2026-05-14T18:03:14.890327+00:00","generated_at":"2026-05-31T05:42:33.060319+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Centessa ORX750 Phase 1 restores normative wakefulness at 2.5 mg, no hepatotoxicity; Phase 2 in Q4","bullets":["2.5 mg dose achieved mean sleep latency of 32 min on MWT vs placebo 17 min (p=0.01), restoring normative wakefulness.","No hepatotoxicity, visual disturbances, or common OX2R agonist AEs observed; all AEs mild/transient.","1.0 mg also statistically significant: mean sleep latency 18 min vs placebo 10 min (p=0.04).","Plans to initiate Phase 2 studies in narcolepsy NT1, NT2, and idiopathic hypersomnia in Q4 2024.","Linear PK supports once-daily dosing; systemic exposure dose-proportional."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-216320","json":"https://secwatch.observer/filing/0001193125-24-216320.json","markdown":"https://secwatch.observer/filing/0001193125-24-216320.md","text":"https://secwatch.observer/filing/0001193125-24-216320.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1847903/000119312524216320/0001193125-24-216320-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1847903/000119312524216320/d857057d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T05:42:33.060319+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}