---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-24-226113"
form_type: "8-K"
ticker: "LNTH"
cik: "0001521036"
company_name: "Lantheus Holdings, Inc."
filed_at: "2024-09-25T23:59:59+00:00"
generated_at: "2026-05-31T01:47:27.774861+00:00"
event_type: "other_material"
sentiment: "neutral"
materiality_score: 0.65
calibrated_materiality_score: 0.65
confidence: "high"
source: SEC EDGAR
---

# Lantheus to release SPLASH trial data in Oct 2024 after 75% OS events reached

## Summary
- Expects to release Phase 3 SPLASH data in October 2024 for 177Lu-PNT2002 in PSMA-expressing mCRPC.
- Release triggered by reaching 75% of protocol-specified target overall survival events.
- Trial randomized 412 patients 2:1; 84.6% of control arm crossed over to PNT2002.
- Primary endpoint is radiographic progression-free survival; 80% of patients from North America.

## SEC filing metadata
- accession: 0001193125-24-226113
- form_type: 8-K
- ticker: LNTH
- cik: 0001521036
- company_name: Lantheus Holdings, Inc.
- filed_at: 2024-09-25T23:59:59+00:00
- event_type: other_material
- sentiment: neutral
- materiality_score: 0.65
- calibrated_materiality_score: 0.65
- confidence: high
- sec_items: 7.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1521036/000119312524226113/0001193125-24-226113-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1521036/000119312524226113/d868473d8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-24-226113
- JSON: https://secwatch.observer/filing/0001193125-24-226113.json
- Plain text: https://secwatch.observer/filing/0001193125-24-226113.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.