{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-246627","form_type":"8-K","ticker":"SPRO","cik":"0001701108","company_name":"Spero Therapeutics, Inc.","filed_at":"2024-10-29T23:59:59+00:00","discovered_at":"2026-05-14T18:03:09.268855+00:00","generated_at":"2026-05-30T09:19:03.390851+00:00","sec_items":["2.02","2.05","7.01","8.01","9.01"],"event_type":"other_material","sentiment":"negative","materiality_score":0.8,"calibrated_materiality_score":0.8,"confidence":"high","headline":"Spero suspends SPR720 development after Phase 2a miss; cuts workforce 39%, extends cash runway to mid-2026","bullets":["SPR720 Phase 2a interim analysis did not meet primary endpoint; 3 cases of reversible grade 3 hepatotoxicity at 1,000 mg dose.","Company restructuring with ~39% workforce reduction; expects ~$1.1M in cash restructuring charges.","Unaudited Q3 2024 cash ~$76.3M; cash runway extended into mid-2026.","Tebipenem HBr PIVOT-PO Phase 3 trial on track for enrollment completion in 2H 2025.","IND cleared for SPR206 Phase 2 trial in HABP/VABP, contingent on non-dilutive funding."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-246627","json":"https://secwatch.observer/filing/0001193125-24-246627.json","markdown":"https://secwatch.observer/filing/0001193125-24-246627.md","text":"https://secwatch.observer/filing/0001193125-24-246627.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1701108/000119312524246627/0001193125-24-246627-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1701108/000119312524246627/d889032d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-30T09:19:03.390851+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}