other material
confidence high
sentiment positive
materiality 0.55
Wave Life Sciences reveals WVE-007 obesity trial startup in Q1 2025, new RNA editing programs
Wave Life Sciences Ltd.
- WVE-007 (INHBE GalNAc-siRNA) on track for Phase 1 in Q1 2025; preclinical data show monotherapy, add-on to GLP-1s, and maintenance potential.
- Three new wholly owned GalNAc-RNA editing programs: PNPLA3, LDLR, APOB targeting cardiometabolic diseases; candidate selection expected in 2025.
- Wave aims to have five GalNAc-siRNA or RNA editing programs in the clinic by 2026.
- Proprietary chemistry innovations (PN backbone, N3U) enhance intracellular delivery and RNA editing efficiency.