{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-24-280112","form_type":"8-K","ticker":"TNYA","cik":"0001858848","company_name":"Tenaya Therapeutics, Inc.","filed_at":"2024-12-17T23:59:59+00:00","discovered_at":"2026-05-14T18:03:10.108013+00:00","generated_at":"2026-05-29T02:34:23.843694+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Tenaya's TN-201 shows robust cardiac transduction, increasing mRNA and protein in 3 HCM patients","bullets":["TN-201 well tolerated at 3E13 vg/kg; no cardiac toxicities or TMA; liver enzyme elevations managed with corticosteroids.","Robust cardiac transduction at Week 8 above preclinical efficacy levels; TN-201 mRNA increased 50% at Week 52 in Patient 1.","MyBP-C protein level increased 3% from Week 8 to 52 in Patient 1; baseline biopsies added for future quantification.","Clinical measures mostly stable/improved: NT-proBNP stable, troponin I normalized in Patient 2; NYHA class improved.","Further data from Cohort 1 and higher-dose Cohort 2 expected in 2025."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-24-280112","json":"https://secwatch.observer/filing/0001193125-24-280112.json","markdown":"https://secwatch.observer/filing/0001193125-24-280112.md","text":"https://secwatch.observer/filing/0001193125-24-280112.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1858848/000119312524280112/0001193125-24-280112-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1858848/000119312524280112/d883027d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-29T02:34:23.843694+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}