other material
confidence high
sentiment neutral
materiality 0.60
Rapport reports positive Phase 1 RAP-219 data; CMO steps down
Rapport Therapeutics, Inc.
- PET trial: dosing regimen used in Phase 2a epilepsy trial exceeded target receptor occupancy (50-70%) within 5 days.
- MAD-2 trial: no sedation or motoric impairment observed; all adverse events Grade 1 or 2.
- Phase 2a focal epilepsy trial on track; topline data expected mid-2025.
- Bradley Galer, M.D., stepped down as Chief Medical Officer; search for successor underway.