other material
confidence high
sentiment neutral
materiality 0.75
Arcus reports $992M cash; Gilead opts out of casdatifan; ARC-20 data shows ORR 25-33%
Arcus Biosciences, Inc.
- Preliminary cash, cash equivalents and marketable securities of $992M as of Dec 31, 2024.
- Gilead's exclusive option for casdatifan expired without exercise; Arcus retains full global rights.
- ARC-20 in ccRCC: 50mg BID median PFS 9.7 months, ORR 25%; 100mg QD ORR 33%.
- Disease control rate 81-87% across cohorts; median DoR not reached; safety acceptable.
- All but two of 26 responders remained on treatment; one discontinuation due to anemia.