---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-25-048423"
form_type: "8-K"
ticker: "SYRE"
cik: "0001636282"
company_name: "Spyre Therapeutics, Inc."
filed_at: "2025-03-06T23:59:59+00:00"
generated_at: "2026-05-25T06:08:05.922583+00:00"
event_type: "other_material"
sentiment: "negative"
materiality_score: 0.75
calibrated_materiality_score: 0.75
confidence: "high"
source: SEC EDGAR
---

# Spyre dismisses PwC as auditor, appoints KPMG; discloses material weakness in controls

## Summary
- PwC dismissed as auditor effective Feb 28, 2025; KPMG appointed as new independent auditor for FY2025.
- No disagreements with PwC on accounting principles; material weakness identified as of Dec 31, 2024 in controls over EPS calculation for convertible preferred stock.
- Material weakness led to restatement of FY2023 consolidated financial statements.
- PwC's reports for FY2024 and FY2023 were unqualified.

## SEC filing metadata
- accession: 0001193125-25-048423
- form_type: 8-K
- ticker: SYRE
- cik: 0001636282
- company_name: Spyre Therapeutics, Inc.
- filed_at: 2025-03-06T23:59:59+00:00
- event_type: other_material
- sentiment: negative
- materiality_score: 0.75
- calibrated_materiality_score: 0.75
- confidence: high
- sec_items: 4.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1636282/000119312525048423/0001193125-25-048423-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1636282/000119312525048423/d861533d8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-25-048423
- JSON: https://secwatch.observer/filing/0001193125-25-048423.json
- Plain text: https://secwatch.observer/filing/0001193125-25-048423.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.