{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-25-050334","form_type":"8-K","ticker":"BEAM","cik":"0001745999","company_name":"Beam Therapeutics Inc.","filed_at":"2025-03-10T23:59:59+00:00","discovered_at":"2026-05-14T18:03:04.695029+00:00","generated_at":"2026-05-25T01:50:46.422218+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Beam reports positive initial Phase 1/2 data for BEAM-302 in AATD; total AAT exceeds protective threshold","bullets":["BEAM-302 well tolerated at all doses; no serious AEs or dose-limiting toxicities observed.","Single 60 mg dose achieved mean total AAT of 12.4 µM at Day 28, exceeding 11 µM protective threshold.","Mutant Z-AAT reduced up to 78% from baseline at 60 mg dose level.","First clinical evidence of precise genetic correction of a disease-causing mutation via base editing.","Dose escalation to continue; further data expected at medical conference in H2 2025; Part B dosing planned H2 2025."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-25-050334","json":"https://secwatch.observer/filing/0001193125-25-050334.json","markdown":"https://secwatch.observer/filing/0001193125-25-050334.md","text":"https://secwatch.observer/filing/0001193125-25-050334.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1745999/000119312525050334/0001193125-25-050334-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1745999/000119312525050334/d922493d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-25T01:50:46.422218+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}