{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-25-063184","form_type":"8-K","ticker":"WVE","cik":"0001631574","company_name":"Wave Life Sciences Ltd.","filed_at":"2025-03-26T23:59:59+00:00","discovered_at":"2026-05-14T18:03:04.245360+00:00","generated_at":"2026-05-24T04:58:49.723050+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Wave reports positive Phase 2 FORWARD-53 data for WVE-N531 in DMD; plans NDA in 2026","bullets":["TTR improved 3.8 seconds vs natural history (p<0.05); fibrosis reduced 28.6% (p<0.01); CK declined 50%.","Mean dystrophin 7.8% (88% >5%); muscle health reversal shown; no SAEs.","FDA confirms accelerated approval pathway; NDA filing planned in 2026 based on all FORWARD-53 data.","Monthly dosing supported by 61-day half-life; additional DMD exons (52,51,45,44) CTAs expected in 2026 addressing ~$2.4B US market.","Pipeline milestones: WVE-006 AATD data, WVE-007 obesity data H2 2025, WVE-003 HD IND H2 2025."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-25-063184","json":"https://secwatch.observer/filing/0001193125-25-063184.json","markdown":"https://secwatch.observer/filing/0001193125-25-063184.md","text":"https://secwatch.observer/filing/0001193125-25-063184.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1631574/000119312525063184/0001193125-25-063184-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1631574/000119312525063184/d918658d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-24T04:58:49.723050+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}