---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-25-100433"
form_type: "8-K"
ticker: "SPRO"
cik: "0001701108"
company_name: "Spero Therapeutics, Inc."
filed_at: "2025-04-28T23:59:59+00:00"
generated_at: "2026-05-23T05:02:50.625097+00:00"
event_type: "leadership"
sentiment: "neutral"
materiality_score: 0.75
calibrated_materiality_score: 0.75
confidence: "high"
source: SEC EDGAR
---

# Esther Rajavelu named Spero CEO effective May 2; former CEO Sath Shukla departs

## Summary
- Esther Rajavelu appointed President and CEO effective May 2, 2025; nominated for board election at annual meeting.
- Rajavelu continues as CFO and Treasurer; base salary $620K, target bonus 50%, 185,000 RSUs vesting over 4 years.
- Former CEO Sath Shukla mutually separates; receives salary continuation of $615,825, cash bonus $307,913, and retention bonus $452,813.
- Company expects update on PIVOT-PO Phase 3 trial for tebipenem HBr this quarter.

## SEC filing metadata
- accession: 0001193125-25-100433
- form_type: 8-K
- ticker: SPRO
- cik: 0001701108
- company_name: Spero Therapeutics, Inc.
- filed_at: 2025-04-28T23:59:59+00:00
- event_type: leadership
- sentiment: neutral
- materiality_score: 0.75
- calibrated_materiality_score: 0.75
- confidence: high
- sec_items: 5.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1701108/000119312525100433/0001193125-25-100433-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1701108/000119312525100433/d807820d8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-25-100433
- JSON: https://secwatch.observer/filing/0001193125-25-100433.json
- Plain text: https://secwatch.observer/filing/0001193125-25-100433.txt

## Key facts
- Executive change
  Esther Rajavelu was appointed as President and Chief Executive Officer at Spero Therapeutics, Inc..
  - Action: appointed
  - Role: President and Chief Executive Officer
  source text: On April 28, 2025, Spero Therapeutics, Inc. (the “Company”) announced that effective as of May 2, 2025 (the “Effective Date”), Esther Rajavelu will serve as the Company’s President and Chief Executive Officer.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1701108/000119312525100433/0001193125-25-100433-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.