{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-25-115489","form_type":"8-K","ticker":"WVE","cik":"0001631574","company_name":"Wave Life Sciences Ltd.","filed_at":"2025-05-08T23:59:59+00:00","discovered_at":"2026-05-14T18:02:49.133996+00:00","generated_at":"2026-05-22T04:38:25.693737+00:00","sec_items":["2.02","7.01","9.01"],"event_type":"earnings","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Wave Life Sciences Q1 2025 net loss $46.9M; pipeline progress in obesity, AATD, DMD, HD","bullets":["Net loss of $46.9M vs $31.6M prior year; revenue $9.2M (down from $12.5M). Cash $243.1M, runway into 2027.","Obesity: dosing complete in first two INLIGHT cohorts for WVE-007; clinical data expected 2H 2025.","AATD: RestorAATion-2 dosing at 200 mg Q2W and 400 mg single dose; data on multiple cohorts due 3Q and fall 2025.","DMD: Positive 48-week FORWARD-53 data with 3.8 sec improvement in TTR vs natural history; NDA submission planned 2026.","HD: IND submission expected 2H 2025 for potentially registrational Phase 2/3 study of WVE-003."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-25-115489","json":"https://secwatch.observer/filing/0001193125-25-115489.json","markdown":"https://secwatch.observer/filing/0001193125-25-115489.md","text":"https://secwatch.observer/filing/0001193125-25-115489.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1631574/000119312525115489/0001193125-25-115489-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1631574/000119312525115489/d892783d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-22T04:38:25.693737+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}