{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-25-142126","form_type":"8-K","ticker":"BMEA","cik":"0001840439","company_name":"Biomea Fusion, Inc.","filed_at":"2025-06-17T23:59:59+00:00","discovered_at":"2026-05-14T18:02:50.066700+00:00","generated_at":"2026-05-19T05:07:16.477349+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"BMF-650 preclinical shows 12-15% weight loss in obese monkeys; IND on track H2 2025","bullets":["28-day study in 15 obese cynomolgus monkeys; oral BMF-650 at 10 or 30 mg/kg daily.","Weight loss of 12% (10 mg/kg) and 15% (30 mg/kg) from baseline at Day 28.","Daily food intake reduced to 35g (10 mg/kg) and 16g (30 mg/kg) vs 109g for vehicle.","IND submission for BMF-650 on track for second half of 2025.","Full preclinical data set planned for upcoming medical conference presentation."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-25-142126","json":"https://secwatch.observer/filing/0001193125-25-142126.json","markdown":"https://secwatch.observer/filing/0001193125-25-142126.md","text":"https://secwatch.observer/filing/0001193125-25-142126.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1840439/000119312525142126/0001193125-25-142126-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1840439/000119312525142126/d915732d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-19T05:07:16.477349+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}