---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-25-142126"
form_type: "8-K"
ticker: "BMEA"
cik: "0001840439"
company_name: "Biomea Fusion, Inc."
filed_at: "2025-06-17T23:59:59+00:00"
generated_at: "2026-05-19T05:07:16.477349+00:00"
event_type: "other_material"
sentiment: "positive"
materiality_score: 0.6
calibrated_materiality_score: 0.6
confidence: "high"
source: SEC EDGAR
---

# BMF-650 preclinical shows 12-15% weight loss in obese monkeys; IND on track H2 2025

## Summary
- 28-day study in 15 obese cynomolgus monkeys; oral BMF-650 at 10 or 30 mg/kg daily.
- Weight loss of 12% (10 mg/kg) and 15% (30 mg/kg) from baseline at Day 28.
- Daily food intake reduced to 35g (10 mg/kg) and 16g (30 mg/kg) vs 109g for vehicle.
- IND submission for BMF-650 on track for second half of 2025.
- Full preclinical data set planned for upcoming medical conference presentation.

## SEC filing metadata
- accession: 0001193125-25-142126
- form_type: 8-K
- ticker: BMEA
- cik: 0001840439
- company_name: Biomea Fusion, Inc.
- filed_at: 2025-06-17T23:59:59+00:00
- event_type: other_material
- sentiment: positive
- materiality_score: 0.6
- calibrated_materiality_score: 0.6
- confidence: high
- sec_items: 7.01, 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1840439/000119312525142126/0001193125-25-142126-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1840439/000119312525142126/d915732d8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-25-142126
- JSON: https://secwatch.observer/filing/0001193125-25-142126.json
- Plain text: https://secwatch.observer/filing/0001193125-25-142126.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.