Assembly Bio reports 94% reduction in HSV-2 shedding with ABI-5366 350mg weekly in Phase 1b

ASSEMBLY BIOSCIENCES, INC.

94% reduction in HSV-2 shedding rate (p<0.01) for 350mg weekly dose vs placebo over 29-day evaluation.
98% reduction in high viral load shedding (p<0.05) and 94% reduction in genital lesion rate (p<0.01) with 350mg weekly.
ABI-5366 well-tolerated; majority of TEAEs Grade 1-2; no serious adverse events reported.
PK supports weekly and potential monthly dosing; Phase 2 preparation initiated; chronic tox studies complete.
Gilead has opt-in rights to the helicase-primase program; ABI-1179 and monthly cohort data expected fall 2025.

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