Aptose Biosciences appoints EY as independent auditor, replacing KPMG

Aptose Biosciences Inc.

KPMG informed company it would not stand for re-appointment for 2025 annual audit.
Board approved EY as independent auditor; shareholders voted approval at reconvened meeting on August 22, 2025.
No disagreements or reportable events between company and KPMG during past two fiscal years.
KPMG letter agreeing with disclosures attached as Exhibit 16.1.

item 4.01item 9.01

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