Zymeworks discontinues ZW171 Phase 1 after dose escalation; benefit-risk profile unfavorable

Zymeworks Inc.

Decision based on completed dose escalation in ovarian and NSCLC patients; MTD established but benefit-risk not supportive.
Dose-limiting toxicities consistent with mesothelin-related on-target off-tumor toxicity; CRS was well-managed.
Ongoing participants may continue at investigator discretion; discontinued patients remain in safety follow-up.
Pipeline continues: ZW191 Phase 1 ongoing, ZW251 Phase 1 expected 2025, ZW209 IND filing planned H1 2026.

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