{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-25-197605","form_type":"8-K","ticker":"IDYA","cik":"0001676725","company_name":"IDEAYA Biosciences, Inc.","filed_at":"2025-09-08T23:59:59+00:00","discovered_at":"2026-05-14T18:02:44.615652+00:00","generated_at":"2026-05-17T07:37:49.822512+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.78,"calibrated_materiality_score":0.78,"confidence":"high","headline":"IDEAYA reports positive Phase 1 data for IDE849 in SCLC, positive Phase 2 darovasertib in UM, positive IDE397 combo data","bullets":["IDE849 (DLL3 ADC) showed 73.2% ORR (52/71) and 47.9% confirmed ORR in SCLC at >=2.4 mg/kg; median PFS 6.7 months.","Darovasertib neoadjuvant UM trial: 76% (16/21) achieved >=20% tumor shrinkage; 48% had >=20% reduction in simulated radiation dose.","IDE397 (MAT2A) + Trodelvy in MTAP-del UC: 33% ORR at DL1 (3cPR), 57% ORR at DL2 (3cPR+1uPR); DCR up to 100%.","Phase 3 OptimUM-10 trial for darovasertib in neoadjuvant primary UM initiated Q2 2025; additional data at ESMO Oct 2025."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-25-197605","json":"https://secwatch.observer/filing/0001193125-25-197605.json","markdown":"https://secwatch.observer/filing/0001193125-25-197605.md","text":"https://secwatch.observer/filing/0001193125-25-197605.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1676725/000119312525197605/0001193125-25-197605-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1676725/000119312525197605/d38716d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-17T07:37:49.822512+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}