{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-25-235533","form_type":"8-K","ticker":"CABA","cik":"0001759138","company_name":"Cabaletta Bio, Inc.","filed_at":"2025-10-09T23:59:59+00:00","discovered_at":"2026-05-14T18:02:40.354542+00:00","generated_at":"2026-05-17T04:13:31.215119+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Cabaletta Bio presents first rese-cel data without preconditioning at ESGCT 2025","bullets":["Rese-cel without preconditioning achieved complete B cell depletion in two of three PV patients, with rapid autoantibody reduction and near-complete symptom resolution.","PDAI activity scores improved from baseline to latest follow-up: Patient 1 (24 to 10 at 4 mo), Patient 2 (83 to 3 at 3 mo), Patient 3 (22 to 2 at 1 mo).","All three patients remained off immunomodulators since infusion and are off or tapering steroids as of the September 11, 2025 data cut-off.","CAR T cell expansion kinetics without preconditioning were similar to those observed across 30+ patients dosed with preconditioning in other RESET trials.","No ICANS was reported; one patient had transient grade 1 CRS, and another required steroids for a disease flare that later tapered below baseline."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-25-235533","json":"https://secwatch.observer/filing/0001193125-25-235533.json","markdown":"https://secwatch.observer/filing/0001193125-25-235533.md","text":"https://secwatch.observer/filing/0001193125-25-235533.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1759138/000119312525235533/0001193125-25-235533-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1759138/000119312525235533/caba-20251009.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud","generated_at":"2026-05-17T04:13:31.215119+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}