---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-25-250676"
form_type: "8-K"
ticker: "CABA"
cik: "0001759138"
company_name: "Cabaletta Bio, Inc."
filed_at: "2025-10-27T23:59:59+00:00"
generated_at: "2026-05-17T02:12:30.009654+00:00"
event_type: "other_material"
sentiment: "positive"
materiality_score: 0.8
calibrated_materiality_score: 0.8
confidence: "high"
source: SEC EDGAR
---

# Cabaletta Bio: all DM/ASyS myositis patients meet registrational endpoint; SSc and lupus data positive

## Summary
- All 4 DM/ASyS patients with sufficient follow-up achieved immunomodulatory-free moderate or major TIS response at week 16.
- Initiating DM/ASyS registrational cohort this quarter; plans 14 patients with 16-week primary endpoint of moderate or major TIS.
- All 4 SSc patients with at least 3 months follow-up achieved rCRISS-25 response off all immunomodulators and steroids.
- 7 of 8 lupus patients with sufficient follow-up achieved DORIS remission or renal response; all 9 patients off immunomodulators.
- Expanding RESET-SLE to include no preconditioning cohort; initial data expected 2026; 76 patients enrolled at 77 sites globally.

## SEC filing metadata
- accession: 0001193125-25-250676
- form_type: 8-K
- ticker: CABA
- cik: 0001759138
- company_name: Cabaletta Bio, Inc.
- filed_at: 2025-10-27T23:59:59+00:00
- event_type: other_material
- sentiment: positive
- materiality_score: 0.8
- calibrated_materiality_score: 0.8
- confidence: high
- sec_items: 7.01, 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1759138/000119312525250676/0001193125-25-250676-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1759138/000119312525250676/caba-20251027.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-25-250676
- JSON: https://secwatch.observer/filing/0001193125-25-250676.json
- Plain text: https://secwatch.observer/filing/0001193125-25-250676.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.