{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-25-256682","form_type":"8-K","ticker":"WVE","cik":"0001631574","company_name":"Wave Life Sciences Ltd.","filed_at":"2025-10-29T23:59:59+00:00","discovered_at":"2026-05-14T18:02:39.988785+00:00","generated_at":"2026-05-17T01:39:57.379426+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Wave Life Sciences reports positive target engagement data for WVE-007 in obesity; Activin E reductions up to 85%","bullets":["WVE-007 achieved Activin E reductions of 85% (400mg), 75% (240mg), 56% (75mg) at one month, all highly significant (p<0.0001).","75mg cohort showed durable reduction through 6 months, supporting once or twice yearly dosing.","WVE-007 safe and well tolerated; independent data monitoring committee supported dose expansion and escalation.","Multiple clinical data updates including body composition and weight expected starting 4Q2025.","Announced WVE-008 RNA editing candidate for PNPLA3 liver disease; CTA filing anticipated in 2026."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-25-256682","json":"https://secwatch.observer/filing/0001193125-25-256682.json","markdown":"https://secwatch.observer/filing/0001193125-25-256682.md","text":"https://secwatch.observer/filing/0001193125-25-256682.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1631574/000119312525256682/0001193125-25-256682-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1631574/000119312525256682/d95356d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-17T01:39:57.379426+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}