Lexicon files prospectus supplement for $75M ATM equity facility; no sales to date

LEXICON PHARMACEUTICALS, INC.

Filed prospectus supplement for at-the-market offering of up to $75M of common stock through Jefferies LLC.
No shares have been sold under the facility as of November 6, 2025.
Legal opinion from Vinson & Elkins L.L.P. on share validity filed as Exhibit 5.1.
Facility originally established under Open Market Sale Agreement dated December 29, 2023.

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