Lexicon corrects prospectus error on EY internal control audit exemption

LEXICON PHARMACEUTICALS, INC.

Prospectus supplement inadvertently stated EY audited internal controls as of Dec 31, 2024.
As a smaller reporting company/non-accelerated filer, Lexicon is exempt from such audit; EY did not perform it.
Correction relates to existing $75M at-the-market equity facility with Jefferies LLC.
No impact on financial statements or current business operations.

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