other material
confidence high
sentiment negative
materiality 0.85
Korro Bio, Inc. (KRRO): restructuring charge — Korro Bio Q3 net loss $18.1M; cuts workforce 34%; Novo collaboration paused; KRRO-110 misses functional protein target
Korro Bio, Inc.
- Cash, equivalents and securities $102.5M at Sept 30, 2025; net loss $18.1M for Q3.
- Workforce reduction of ~34%; expects one-time restructuring charges of ~$2.4M in Q4 2025.
- KRRO-110 produced functional M-AAT protein but peak total AAT ~10 µM missed protective 11 µM threshold; pivoting to GalNAc construct for AATD.
- Nominated KRRO-121 for hyperammonemia; first-in-human filing anticipated H2 2026.
- Novo Nordisk collaboration paused for 12 months; CMO Dr. Olugemo resigned effective Nov 12.