{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-25-308781","form_type":"8-K","ticker":"STOK","cik":"0001623526","company_name":"Stoke Therapeutics, Inc.","filed_at":"2025-12-05T23:59:59+00:00","discovered_at":"2026-05-14T18:02:39.956164+00:00","generated_at":"2026-05-16T14:15:33.077873+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Stoke and Biogen present data supporting zorevunersen's disease-modifying potential for Dravet syndrome","bullets":["Propensity score weighted analysis shows statistically significant reductions in major motor seizure frequency at 6 months (70mg loading dose) vs natural history.","Improvements in cognition and behavior (Vineland-3) at 18 months with 45mg dosing; durable effects through 24 months.","EEG analysis reveals dose-dependent decrease in abnormal brain activity; reduction in EEG abnormality correlated with seizure reduction.","Safety: 81 patients, >800 doses; CSF protein elevations in 42% (Phase 1/2a) and 86% (OLE) but no clinical manifestations; 3 unrelated deaths (2 SUDEP, 1 malnutrition).","Data are consistent with endpoints in ongoing Phase 3 EMPEROR study (week 28 primary, 18-month secondary)."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-25-308781","json":"https://secwatch.observer/filing/0001193125-25-308781.json","markdown":"https://secwatch.observer/filing/0001193125-25-308781.md","text":"https://secwatch.observer/filing/0001193125-25-308781.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1623526/000119312525308781/0001193125-25-308781-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1623526/000119312525308781/d272524d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-16T14:15:33.077873+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}