{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-25-310469","form_type":"8-K","ticker":"LYEL","cik":"0001806952","company_name":"Lyell Immunopharma, Inc.","filed_at":"2025-12-08T23:59:59+00:00","discovered_at":"2026-05-14T18:02:40.528345+00:00","generated_at":"2026-05-16T14:02:37.710712+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Lyell Immunopharma reports 93% ORR in 3L+ LBCL for ronde-cel at ASH","bullets":["In 3L+ setting (n=29 evaluable): 93% ORR, 76% CR; median PFS 18 months at 12-month median follow-up.","In 2L setting (n=18 evaluable, 94% primary refractory): 83% ORR, 61% CR; median duration of CR not reached.","Safety (n=69): no Grade ≥3 CRS; one Grade ≥3 ICANS case (4% with dex prophylaxis); no treatment-related deaths.","Ronde-cel showed up to 3-fold higher expansion vs approved CD19 CAR-T products and higher memory-cell phenotype.","Data cutoff Sep 5, 2025; ronde-cel is dual-targeting CD19/CD20 CAR-T with CD62L enrichment manufacturing."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-25-310469","json":"https://secwatch.observer/filing/0001193125-25-310469.json","markdown":"https://secwatch.observer/filing/0001193125-25-310469.md","text":"https://secwatch.observer/filing/0001193125-25-310469.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1806952/000119312525310469/0001193125-25-310469-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1806952/000119312525310469/d35459d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-16T14:02:37.710712+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}