{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-25-311251","form_type":"8-K","ticker":"ASMB","cik":"0001426800","company_name":"ASSEMBLY BIOSCIENCES, INC.","filed_at":"2025-12-08T23:59:59+00:00","discovered_at":"2026-05-14T18:02:39.384954+00:00","generated_at":"2026-05-16T13:56:36.921542+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.8,"calibrated_materiality_score":0.8,"confidence":"high","headline":"Assembly Bio reports Phase 1b data: ABI-1179 98% HSV-2 shedding reduction, ABI-5366 monthly 76%","bullets":["ABI-1179 50 mg weekly: 98% HSV-2 shedding reduction (p<0.01), exceeds 80-85% target; 91% lesion reduction (p<0.01).","ABI-1179: >99% reduction in high viral load shedding, a transmission surrogate.","ABI-5366 monthly dose: 76% HSV-2 shedding reduction (p<0.01), 88% lesion reduction (p=0.01), 81% high viral load reduction.","ABI-5366 weekly 350 mg confirmed: 94% shedding, 97% lesion reduction vs placebo.","Both candidates well-tolerated; Phase 2 planning for ABI-1179 and ABI-5366 weekly; monthly optimization ongoing."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-25-311251","json":"https://secwatch.observer/filing/0001193125-25-311251.json","markdown":"https://secwatch.observer/filing/0001193125-25-311251.md","text":"https://secwatch.observer/filing/0001193125-25-311251.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1426800/000119312525311251/0001193125-25-311251-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1426800/000119312525311251/asmb-20251208.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-16T13:56:36.921542+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}