{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-26-009829","form_type":"8-K","ticker":"MREO","cik":"0001719714","company_name":"Mereo BioPharma Group plc","filed_at":"2026-01-12T23:59:59+00:00","discovered_at":"2026-05-14T18:02:35.996176+00:00","generated_at":"2026-05-16T10:54:12.814550+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"negative","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Mereo BioPharma reports setrusumab Phase 3 miss; extends cash runway to mid-2027","bullets":["Cash and equivalents $41M as of Dec 31, 2025; reduced pre-commercial spend extends runway to mid-2027.","Setrusumab Phase 3 Orbit/Cosmic missed primary fracture-rate endpoints; BMD secondary endpoint met (p<0.001).","Alvelestat Phase 3 plan: single 220-patient trial over 18 months; partnering discussions ongoing.","Vantictumab out-licensed to ashibio for ADO2; Phase 2 expected 2H 2026; Mereo retains EU rights.","No approved OI therapies in US/EU except Italy's neridronate; high unmet need remains."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-26-009829","json":"https://secwatch.observer/filing/0001193125-26-009829.json","markdown":"https://secwatch.observer/filing/0001193125-26-009829.md","text":"https://secwatch.observer/filing/0001193125-26-009829.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1719714/000119312526009829/0001193125-26-009829-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1719714/000119312526009829/mreo-20260112.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-16T10:54:12.814550+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}