8-K
filed January 12, 2026, 6:59 PM ET
ticker SYRE
CIK 0001636282
leadership
confidence high
sentiment positive
materiality 0.70
Spyre appoints CCO, accelerates SPY001 readout to Q2; six proof-of-concept reads expected in 2026
Spyre Therapeutics, Inc.
- Appointed Kate Tansey Chevlen as CCO; previously Amgen VP, Global Marketing Head for Immunology.
- SPY001 enrollment complete ahead of schedule; SKYLINE Part A readouts now expected to begin Q2 2026.
- Six total proof-of-concept readouts planned: 3 from SKYLINE (UC) and 3 from SKYWAY (RA, PsA, axSpA) by 4Q 2026.
- Pro forma cash $783M as of Sept 30, 2025, including Oct 2025 offering net proceeds; runway into H2 2028.
Machine-readable event card
- schema_version
- secwatch.filing_event.v1
- accession
- 0001193125-26-009894
- form_type
- 8-K
- ticker
- SYRE
- cik
- 0001636282
- company_name
- Spyre Therapeutics, Inc.
- filed_at
- 2026-01-12T23:59:59+00:00
- discovered_at
- 2026-05-14T18:02:35.705125+00:00
- generated_at
- 2026-05-16T10:53:05.431069+00:00
- sec_items
- ["7.01", "9.01"]
- event_type
- leadership
- sentiment
- positive
- materiality_score
- 0.7
- calibrated_materiality_score
- 0.7
- confidence
- high
- secwatch_canonical_url
- https://secwatch.observer/filing/0001193125-26-009894
- json_url
- https://secwatch.observer/filing/0001193125-26-009894.json
- markdown_url
- https://secwatch.observer/filing/0001193125-26-009894.md
- text_url
- https://secwatch.observer/filing/0001193125-26-009894.txt
- edgar_index_url
- https://www.sec.gov/Archives/edgar/data/1636282/000119312526009894/0001193125-26-009894-index.htm
- edgar_primary_document_url
- https://www.sec.gov/Archives/edgar/data/1636282/000119312526009894/d28401d8k.htm
- generated_by_model
- deepseek-v4-flash:cloud@v2
- review_status
- machine_generated
- human_reviewed
- false
- corrected
- false
- correction_note
- null
- correction_timestamp
- null
- superseded_by
- null
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