{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-26-034538","form_type":"8-K","ticker":"NERV","cik":"0001598646","company_name":"Minerva Neurosciences, Inc.","filed_at":"2026-02-03T23:59:59+00:00","discovered_at":"2026-05-14T18:02:35.589391+00:00","generated_at":"2026-05-16T05:19:51.966124+00:00","sec_items":["7.01","8.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Minerva unveils Phase 3 trial design for roluperidone; planned start Q2 2026","bullets":["Phase 3 trial to enroll 380 patients with negative symptoms of schizophrenia; 1:1 randomization to placebo or 64 mg roluperidone.","Primary endpoint: change from baseline in PANSS Marder negative symptoms factor score (NSFS) at 12 weeks.","After 12 weeks, patients enter 40-week relapse assessment phase; crossover to roluperidone or antipsychotics.","Topline efficacy results expected H2 2027; relapse assessment data expected H2 2028.","Trial initiation (first patient screened) subject to FDA feedback, targeted Q2 2026."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-26-034538","json":"https://secwatch.observer/filing/0001193125-26-034538.json","markdown":"https://secwatch.observer/filing/0001193125-26-034538.md","text":"https://secwatch.observer/filing/0001193125-26-034538.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1598646/000119312526034538/0001193125-26-034538-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1598646/000119312526034538/d896733d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-16T05:19:51.966124+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}