{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-26-039399","form_type":"8-K","ticker":"SPRB","cik":"0001683553","company_name":"SPRUCE BIOSCIENCES, INC.","filed_at":"2026-02-05T23:59:59+00:00","discovered_at":"2026-05-14T18:02:35.885853+00:00","generated_at":"2026-05-16T04:28:23.070500+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Spruce Biosciences reports long-term TA-ERT data stabilizing cognition and motor skills in MPS IIIB","bullets":["TA-ERT normalized CSF HS-NRE and stabilized Bayley-III cognitive scores over up to 6 years vs decline in natural history.","VABS-II analysis showed stabilization of receptive/expressive communication and fine/gross motor skills.","Sibling case study: treated child at 12.1 years spoke words and self-fed; untreated at 11.7 years was nonverbal and dependent.","Safety consistent with ICV route; ~6,000 doses administered to 22 patients without new safety signals.","Spruce plans to advance TA-ERT through BLA submission and potential FDA approval for MPS IIIB."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-26-039399","json":"https://secwatch.observer/filing/0001193125-26-039399.json","markdown":"https://secwatch.observer/filing/0001193125-26-039399.md","text":"https://secwatch.observer/filing/0001193125-26-039399.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1683553/000119312526039399/0001193125-26-039399-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1683553/000119312526039399/sprb-20260205.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-16T04:28:23.070500+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}