---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-26-071557"
form_type: "8-K"
ticker: "ALEC"
cik: "0001653087"
company_name: "Alector, Inc."
filed_at: "2026-02-25T23:59:59+00:00"
generated_at: "2026-05-16T00:20:16.029745+00:00"
event_type: "earnings"
sentiment: "negative"
materiality_score: 0.7
calibrated_materiality_score: 0.7
confidence: "high"
source: SEC EDGAR
---

# Alector Q4 net loss $37.3M ($0.34/share); revenue down 89% YoY; cash $256M

## Summary
- Q4 2025 net loss $37.3M vs $2.1M in Q4 2024; full-year net loss $142.9M ($1.39/share).
- Collaboration revenue fell to $6.2M in Q4 from $54.2M a year earlier; full-year revenue $21M.
- Cash, equivalents and investments $256M; company expects runway at least through 2027.
- Independent interim futility analysis for PROGRESS-AD Phase 2 trial of nivisnebart expected H1 2026.
- ABC-led pipeline advancing: AL137 IND filing planned Q4 2026/Q1 2027; AL050 IND target 2027.

## SEC filing metadata
- accession: 0001193125-26-071557
- form_type: 8-K
- ticker: ALEC
- cik: 0001653087
- company_name: Alector, Inc.
- filed_at: 2026-02-25T23:59:59+00:00
- event_type: earnings
- sentiment: negative
- materiality_score: 0.7
- calibrated_materiality_score: 0.7
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1653087/000119312526071557/0001193125-26-071557-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1653087/000119312526071557/alec-20260225.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-26-071557
- JSON: https://secwatch.observer/filing/0001193125-26-071557.json
- Plain text: https://secwatch.observer/filing/0001193125-26-071557.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.