secwatch.observer — SEC 8-K summary
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Issuer:     Alector, Inc. (ALEC)
CIK:        0001653087
Form:       8-K
Filed at:   2026-02-25T23:59:59+00:00
Accession:  0001193125-26-071557
Event type: earnings
Sentiment:  negative
Materiality: 0.70
Item codes: 2.02, 9.01
LLM model:  deepseek-v4-flash:cloud@v2

Alector Q4 net loss $37.3M ($0.34/share); revenue down 89% YoY; cash $256M
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- Q4 2025 net loss $37.3M vs $2.1M in Q4 2024; full-year net loss $142.9M ($1.39/share).
- Collaboration revenue fell to $6.2M in Q4 from $54.2M a year earlier; full-year revenue $21M.
- Cash, equivalents and investments $256M; company expects runway at least through 2027.
- Independent interim futility analysis for PROGRESS-AD Phase 2 trial of nivisnebart expected H1 2026.
- ABC-led pipeline advancing: AL137 IND filing planned Q4 2026/Q1 2027; AL050 IND target 2027.

Source:
  EDGAR index:    https://www.sec.gov/Archives/edgar/data/1653087/000119312526071557/0001193125-26-071557-index.htm
  Primary doc:    https://www.sec.gov/Archives/edgar/data/1653087/000119312526071557/alec-20260225.htm
  HTML page:      https://secwatch.observer/filing/0001193125-26-071557

License: Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer