---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-26-098489"
form_type: "8-K"
ticker: "SEPN"
cik: "0001984086"
company_name: "Septerna, Inc."
filed_at: "2026-03-09T23:59:59+00:00"
generated_at: "2026-05-15T18:14:38.503346+00:00"
event_type: "earnings"
sentiment: "positive"
materiality_score: 0.65
calibrated_materiality_score: 0.65
confidence: "high"
source: SEC EDGAR
---

# Septerna posts Q4 net loss $10.7M, highlights positive Phase 1 data for SEP-631

## Summary
- Phase 1 data: SEP-631 well-tolerated, once-daily oral dosing, complete wheal inhibition at 10 mg; Phase 2b in CSU planned H2 2026.
- SEP-479 PTH1R agonist on track for Phase 1 initiation in first half of 2026.
- Cash $548.7M at Dec 31, 2025; runway at least into 2029 (includes $195M upfront from Novo Nordisk).
- Q4 2025 revenue $24.1M (collaboration revenue); net loss $10.7M vs $20.7M loss in Q4 2024.
- Appointed Mark A. Wilson as chief legal officer in January 2026.

## SEC filing metadata
- accession: 0001193125-26-098489
- form_type: 8-K
- ticker: SEPN
- cik: 0001984086
- company_name: Septerna, Inc.
- filed_at: 2026-03-09T23:59:59+00:00
- event_type: earnings
- sentiment: positive
- materiality_score: 0.65
- calibrated_materiality_score: 0.65
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1984086/000119312526098489/0001193125-26-098489-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1984086/000119312526098489/sepn-20260309.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-26-098489
- JSON: https://secwatch.observer/filing/0001193125-26-098489.json
- Plain text: https://secwatch.observer/filing/0001193125-26-098489.txt

## Key facts
- Earnings Releases
  Septerna, Inc. reported the fourth quarter and full year ended December 31, 2025 results: revenue $24.1 million for the fourth quarter of 2025 and $46.0 million for the full year ended December 31, 2025, net income Net loss was $10.7 million for the fourth quarter of 2025 and $48.9 million for the full year ended December 31, 2025.
  - Period: the fourth quarter and full year ended December 31, 2025
  - Revenue: $24.1 million for the fourth quarter of 2025 and $46.0 million for the full year ended December 31, 2025
  - Net income: Net loss was $10.7 million for the fourth quarter of 2025 and $48.9 million for the full year ended December 31, 2025
  - Result: reported results
  source text: On March 9, 2026, Septerna, Inc. (the “Company”) announced its financial results and business highlights for the fourth quarter and year ended December 31, 2025.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1984086/000119312526098489/0001193125-26-098489-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.