OnKure Therapeutics Q4 2025 net loss narrows to $13.5M; expects March data readouts

OnKure Therapeutics, Inc.

Net loss of $13.5M ($0.99/sh) for Q4 2025 vs $17.4M ($1.37/sh) in Q4 2024; expenses decreased.
Cash and equivalents $59.1M as of Dec 31, 2025.
PIKture-01 trial (OKI-219) data expected March 2026 across mono, combo, and triplet arms.
Next-gen PI3Kα pan-mutant inhibitor candidate for HR+ breast cancer to be announced March 2026.
R&D expenses $10.7M vs $14.4M YoY; G&A $3.4M vs $4.3M.

Key facts

Extracted from this filing and checked against the source text.

Earnings Releases SEC 8-K Item 2.02 confidence 0.9

OnKure Therapeutics, Inc. reported the fourth quarter ended December 31, 2025 results: net income $13.5 million, EPS $0.99 per share.

Period: the fourth quarter ended December 31, 2025
Net income: $13.5 million
EPS: $0.99 per share
Result: reported results

Exact text from the filing

Net loss and net loss per share for the fourth quarter of 2025 were $13.5 million, or $0.99 per share

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OnKure Therapeutics, Inc. filing history →

Source: SEC EDGAR

accession 0001193125-26-104104

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