---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-26-131746"
form_type: "8-K"
ticker: "ANNX"
cik: "0001528115"
company_name: "Annexon, Inc."
filed_at: "2026-03-30T23:59:59+00:00"
generated_at: "2026-05-15T08:22:29.884508+00:00"
event_type: "earnings"
sentiment: "neutral"
materiality_score: 0.85
calibrated_materiality_score: 0.85
confidence: "high"
source: SEC EDGAR
---

# Annexon reports Q4 and FY2025 net loss of $48.3M and $208.5M; cash $238.3M; vonaprument Phase 3 data due Q4 2026

## Summary
- Net loss Q4 2025 $48.3M ($0.28/sh) and FY2025 $208.5M ($1.34/sh); FY2024 net loss was $138.2M.
- Cash, equivalents and short-term investments $238.3M at Dec 31, 2025; funds operations into H2 2027.
- R&D expenses $184.7M for FY2025, up from $119.4M due to Phase 3 ARCHER II and regulatory filings.
- Vonaprument Phase 3 ARCHER II topline data in geographic atrophy expected Q4 2026; enrollment completed July 2025.
- Tanruprubart MAA filed in EU for GBS; U.S. BLA submission planned in 2026 based on FORWARD study.

## SEC filing metadata
- accession: 0001193125-26-131746
- form_type: 8-K
- ticker: ANNX
- cik: 0001528115
- company_name: Annexon, Inc.
- filed_at: 2026-03-30T23:59:59+00:00
- event_type: earnings
- sentiment: neutral
- materiality_score: 0.85
- calibrated_materiality_score: 0.85
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1528115/000119312526131746/0001193125-26-131746-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1528115/000119312526131746/annx-20260330.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-26-131746
- JSON: https://secwatch.observer/filing/0001193125-26-131746.json
- Plain text: https://secwatch.observer/filing/0001193125-26-131746.txt

## Key facts
- Earnings Releases
  Annexon, Inc. reported financial results for the fourth quarter and the year ended December 31, 2025.
  - Period: the fourth quarter and the year ended December 31, 2025
  - Result: reported results
  source text: On March 30, 2026, Annexon, Inc. (the “Company”) announced certain financial results for the fourth quarter and the year ended December 31, 2025.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1528115/000119312526131746/0001193125-26-131746-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.