---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-26-212069"
form_type: "8-K"
ticker: "TECX"
cik: "0001681087"
company_name: "Tectonic Therapeutic, Inc."
filed_at: "2026-05-07T23:59:59+00:00"
generated_at: "2026-05-14T21:51:00.247772+00:00"
event_type: "earnings"
sentiment: "negative"
materiality_score: 0.6
calibrated_materiality_score: 0.6
confidence: "high"
source: SEC EDGAR
---

# Tectonic Therapeutic Q1 net loss $25.2M; TX45 APEX Phase 2 enrollment near complete

## Summary
- Net loss $25.2M in Q1 2026 vs. $15.9M in Q1 2025; R&D expense $20.9M (up $7.9M YoY).
- Cash $236.9M as of Mar 31, 2026, providing runway into Q4 2028.
- TX45 APEX Phase 2 in PH-HFpEF enrollment nearing completion; topline data expected late Q4 2026/early Q1 2027.
- TX2100 Phase 1a in HHT ongoing; topline results expected by end of Q3 2026.
- Appointed François Nader as Board Chair and Jessica Chutter as independent director.

## SEC filing metadata
- accession: 0001193125-26-212069
- form_type: 8-K
- ticker: TECX
- cik: 0001681087
- company_name: Tectonic Therapeutic, Inc.
- filed_at: 2026-05-07T23:59:59+00:00
- event_type: earnings
- sentiment: negative
- materiality_score: 0.6
- calibrated_materiality_score: 0.6
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1681087/000119312526212069/0001193125-26-212069-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1681087/000119312526212069/tecx-20260507.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-26-212069
- JSON: https://secwatch.observer/filing/0001193125-26-212069.json
- Plain text: https://secwatch.observer/filing/0001193125-26-212069.txt

## Source-grounded claims
- claim_id: 0753569a82639a3150f00f67175cf18f2d02cd46
  claim: Tectonic Therapeutic, Inc. reported financial results for the first quarter ended March 31, 2026.
  evidence_excerpt: On May 7, 2026, Tectonic Therapeutic, Inc. announced its financial results for the quarter ended March 31, 2026 and provided a general business update.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1681087/000119312526212069/0001193125-26-212069-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.