{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-26-215676","form_type":"8-K","ticker":"MBX","cik":"0001776111","company_name":"MBX Biosciences, Inc.","filed_at":"2026-05-11T23:59:59+00:00","discovered_at":"2026-05-14T18:02:32.887191+00:00","generated_at":"2026-05-14T18:48:42.344310+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"MBX 4291 Phase 1 shows 7% mean weight loss at 8 weeks; MBX 5765 nominated","bullets":["Preliminary blinded data: mean weight loss 7% (range 0-16%) at 8 weeks in first MAD Part B cohort (n=8, incl. 2 placebo).","PK profile supports once-monthly dosing: T1/2Cmax ~26 days, Tmax 13–14 days, dose-proportional PK from 15-180 mg.","MBX 5765 nominated as amycretin prodrug (GLP-1/GIP/GCG/DACRA agonist); IND-enabling studies expected Q2 2026.","Imapextide achieved POC in PBH Phase 2a (glucose nadir +34% at 200 mg); company will not pursue Phase 2b.","12-week MAD Part C data for MBX 4291 remain on track for Q4 2026."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-26-215676","json":"https://secwatch.observer/filing/0001193125-26-215676.json","markdown":"https://secwatch.observer/filing/0001193125-26-215676.md","text":"https://secwatch.observer/filing/0001193125-26-215676.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1776111/000119312526215676/0001193125-26-215676-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1776111/000119312526215676/mbx-20260511.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-14T18:48:42.344310+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}