---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-26-265800"
form_type: "8-K"
ticker: "UPB"
cik: "0002022626"
company_name: "Upstream Bio, Inc."
filed_at: "2026-06-10T20:05:16+00:00"
generated_at: "2026-06-10T20:06:52.555104+00:00"
event_type: "other"
sentiment: "neutral"
materiality_score: 0.1
calibrated_materiality_score: 0.1
confidence: "high"
source: SEC EDGAR
---

# Upstream Bio stockholders elect H. Edward Fleming and Liam Ratcliffe as Class II directors at 2026 Annual Meeting

## Summary
- Both director nominees elected with over 40M votes for; Fleming received 40,715,035 for, Ratcliffe 43,812,021 for.
- Ratification of PricewaterhouseCoopers LLP as independent auditor for FY2026 approved 47,951,313 for, 143,251 against, 6,203 abstain.
- Record date Apr 13, 2026; 54,419,986 shares outstanding, 48,100,767 represented at meeting (quorum).

## SEC filing metadata
- accession: 0001193125-26-265800
- form_type: 8-K
- ticker: UPB
- cik: 0002022626
- company_name: Upstream Bio, Inc.
- filed_at: 2026-06-10T20:05:16+00:00
- event_type: other
- sentiment: neutral
- materiality_score: 0.1
- calibrated_materiality_score: 0.1
- confidence: high
- sec_items: 5.07
- EDGAR index: https://www.sec.gov/Archives/edgar/data/2022626/000119312526265800/0001193125-26-265800-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/2022626/000119312526265800/upb-20260609.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-26-265800
- JSON: https://secwatch.observer/filing/0001193125-26-265800.json
- Plain text: https://secwatch.observer/filing/0001193125-26-265800.txt

## Key facts
- Shareholder Votes
  Upstream Bio, Inc. shareholders approved Election of Class II Directors at the 2026-06-09 meeting.
  - Proposal: director election
  - Outcome: passed
  - Meeting: 2026-06-09
  source text: The Company’s stockholders approved the Class II director nominees recommended for election in Proposal 1 at the Annual Meeting. The results of Proposal 1 were as follows: Class II Director Nominee For Withheld Broker Non-Votes H. Edward Fleming, Jr., M.D. 40,715,035 3,367,258 4,018,474 Liam Ratcliffe, M.B.Ch.B., Ph.D., M.B.A. 43,812,021 270,272 4,018,474
  evidence_url: https://www.sec.gov/Archives/edgar/data/2022626/000119312526265800/0001193125-26-265800-index.htm
- Shareholder Votes
  Upstream Bio, Inc. shareholders approved Ratification of Appointment of Independent Registered Public Accounting Firm at the 2026-06-09 meeting.
  - Proposal: auditor ratification
  - Outcome: passed
  - Meeting: 2026-06-09
  source text: Proposal 2 - Ratification of Appointment of the Company’s Independent Registered Public Accounting Firm The Company’s stockholders ratified the appointment of PwC as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2026. The results of Proposal 2 were as follows: For Against Abstain 47,951,313 143,251 6,203
  evidence_url: https://www.sec.gov/Archives/edgar/data/2022626/000119312526265800/0001193125-26-265800-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.