{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-26-286914","form_type":"8-K","ticker":"TCRT","cik":"0001107421","company_name":"Alaunos Therapeutics, Inc.","filed_at":"2026-06-29T12:30:43+00:00","discovered_at":"2026-06-29T12:35:00.305089+00:00","generated_at":"2026-06-29T12:35:21.818636+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.4,"calibrated_materiality_score":0.4,"confidence":"high","headline":"Alaunos reports ALN1003 preclinical liver-weight finding after body-fat adjustment in DIO mouse study","bullets":["48-day DIO mouse study: ALN1003-treated animals had lower liver weight after adjusting for body fat (ANCOVA p=0.000005; HC3 robust p=0.000015).","Liver-weight finding consistent with lower liver injury enzymes (ALT, AST, ALP) and lower mean NAS score (2.7 vs 5.0 for selected controls).","HOMA-IR remained significant after adjusting for body fat (ANCOVA p=0.0006; HC3 p=0.0014).","Favorable adipose biomarkers: lower leptin, higher adiponectin, higher adiponectin-to-leptin ratio in DIO Study 1.","ALN1003 is non-hormonal, non-incretin small molecule; all data from non-GLP mouse studies, may not translate to humans."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-26-286914","json":"https://secwatch.observer/filing/0001193125-26-286914.json","markdown":"https://secwatch.observer/filing/0001193125-26-286914.md","text":"https://secwatch.observer/filing/0001193125-26-286914.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1107421/000119312526286914/0001193125-26-286914-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1107421/000119312526286914/tcrt-20260629.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-29T12:35:21.818636+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}