---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-26-286914"
form_type: "8-K"
ticker: "TCRT"
cik: "0001107421"
company_name: "Alaunos Therapeutics, Inc."
filed_at: "2026-06-29T12:30:43+00:00"
generated_at: "2026-06-29T12:35:21.818636+00:00"
event_type: "other_material"
sentiment: "neutral"
materiality_score: 0.4
calibrated_materiality_score: 0.4
confidence: "high"
source: SEC EDGAR
---

# Alaunos reports ALN1003 preclinical liver-weight finding after body-fat adjustment in DIO mouse study

## Summary
- 48-day DIO mouse study: ALN1003-treated animals had lower liver weight after adjusting for body fat (ANCOVA p=0.000005; HC3 robust p=0.000015).
- Liver-weight finding consistent with lower liver injury enzymes (ALT, AST, ALP) and lower mean NAS score (2.7 vs 5.0 for selected controls).
- HOMA-IR remained significant after adjusting for body fat (ANCOVA p=0.0006; HC3 p=0.0014).
- Favorable adipose biomarkers: lower leptin, higher adiponectin, higher adiponectin-to-leptin ratio in DIO Study 1.
- ALN1003 is non-hormonal, non-incretin small molecule; all data from non-GLP mouse studies, may not translate to humans.

## SEC filing metadata
- accession: 0001193125-26-286914
- form_type: 8-K
- ticker: TCRT
- cik: 0001107421
- company_name: Alaunos Therapeutics, Inc.
- filed_at: 2026-06-29T12:30:43+00:00
- event_type: other_material
- sentiment: neutral
- materiality_score: 0.4
- calibrated_materiality_score: 0.4
- confidence: high
- sec_items: 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1107421/000119312526286914/0001193125-26-286914-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1107421/000119312526286914/tcrt-20260629.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-26-286914
- JSON: https://secwatch.observer/filing/0001193125-26-286914.json
- Plain text: https://secwatch.observer/filing/0001193125-26-286914.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.