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confidence high
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materiality 0.75
Perspective Therapeutics updates ASCO 2026 data; VMT-α-NET shows deepening responses in NETs
Perspective Therapeutics, Inc.
- VMT-α-NET (212Pb for SSTR2+ NETs) shows best response deepens over time; durable disease control across doses; stable renal function in 68 patients.
- VMT01 (212Pb for MC1R+ melanoma) shows preliminary anti-tumor activity at 3.0 mCi dose; well-tolerated with TEAEs in ≥10% of patients.
- PSV359 (212Pb targeting FAP-ɑ) enters Phase 1/2a for advanced solid tumors with improved tumor retention.
- Pipeline also includes CCK2R81 for medullary thyroid cancer and combination with immune checkpoint inhibitors.