{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-26-308409","form_type":"8-K","ticker":"FDMT","cik":"0001650648","company_name":"4D Molecular Therapeutics, Inc.","filed_at":"2026-07-20T12:30:05+00:00","discovered_at":"2026-07-20T12:35:00.300225+00:00","generated_at":"2026-07-20T12:35:04.561861+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.8,"calibrated_materiality_score":0.8,"confidence":"high","headline":"4D Molecular reports positive 2-year Phase 2b data for 4D-150 in wet AMD; 78% treatment burden reduction","bullets":["Overall cohort: 78% reduction in treatment burden (2.7 mean supplemental injections vs 12.0 projected for aflibercept Q8W).","Recently diagnosed subgroup: 87% reduction (1.6 mean supplemental injections vs 12.0).","Dose response maintained in favor of Phase 3 dose (3E10 vg/eye) over 2 years.","Safety: 2.8% (2/71) had transient mild IOI within first 28 weeks; no new inflammation with up to 4+ years follow-up.","No 4D-150-related hypotony, endophthalmitis, vasculitis, or choroidal effusions observed."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-26-308409","json":"https://secwatch.observer/filing/0001193125-26-308409.json","markdown":"https://secwatch.observer/filing/0001193125-26-308409.md","text":"https://secwatch.observer/filing/0001193125-26-308409.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1650648/000119312526308409/0001193125-26-308409-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1650648/000119312526308409/d98747d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-07-20T12:35:04.561861+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}