{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-26-387351","form_type":"8-K","ticker":"IRON","cik":"0001816736","company_name":"Disc Medicine, Inc.","filed_at":"2026-09-10T12:48:26+00:00","discovered_at":"2026-09-10T12:50:01.330270+00:00","generated_at":"2026-09-10T12:50:07.027307+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"DISC-3405 cuts phlebotomy events 85% in PV Phase 2; hematocrit controlled <45%","bullets":["Mean phlebotomy events fell from 4.0 to 0.6 per 26 weeks (p<0.0001) in Cohort A (n=13).","61.5% of patients phlebotomy-free through 26 weeks; 77.8% during maintenance (weeks 12-32, n=9).","Hematocrit maintained <45% through week 26 with improved symptom burden; dose-proportional PK, increased hepcidin.","DISC-3405 well-tolerated; mild injection site reactions; adverse events consistent with underlying disease.","Company plans RESTORE-PV update and sickle cell data by end of 2026; selcodebart FDA feedback expected."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-26-387351","json":"https://secwatch.observer/filing/0001193125-26-387351.json","markdown":"https://secwatch.observer/filing/0001193125-26-387351.md","text":"https://secwatch.observer/filing/0001193125-26-387351.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1816736/000119312526387351/0001193125-26-387351-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1816736/000119312526387351/iron-20260909.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-09-10T12:50:07.027307+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}