{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-26-387890","form_type":"8-K","ticker":"LYEL","cik":"0001806952","company_name":"Lyell Immunopharma, Inc.","filed_at":"2026-09-10T20:13:52+00:00","discovered_at":"2026-09-10T20:15:11.524607+00:00","generated_at":"2026-09-10T20:15:15.877798+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.5,"calibrated_materiality_score":0.5,"confidence":"high","headline":"Lyell completes LYL273 manufacturing transfer to LyFE; Phase 1/2 data and FDA meeting expected 2027","bullets":["Completed technology transfer of LYL273 to LyFE Manufacturing Center in Bothell, WA after FDA review of improved process and analytical methods.","Phase 1/2 trial in relapsed/refractory metastatic colorectal cancer continues enrolling; goal to determine recommended Phase 2 dose and safety plan.","Additional clinical data and End-of-Phase 1 meeting with FDA now expected in 2027.","CEO Lynn Seely notes encouraging clinical activity data and activation of additional clinical sites for expansion phase."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-26-387890","json":"https://secwatch.observer/filing/0001193125-26-387890.json","markdown":"https://secwatch.observer/filing/0001193125-26-387890.md","text":"https://secwatch.observer/filing/0001193125-26-387890.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1806952/000119312526387890/0001193125-26-387890-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1806952/000119312526387890/d278670d8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-09-10T20:15:15.877798+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}