---
schema_version: "secwatch.filing_event.v1"
accession: "0001193125-26-420684"
form_type: "8-K"
ticker: "BMEA"
cik: "0001840439"
company_name: "Biomea Fusion, Inc."
filed_at: "2026-10-13T21:35:08+00:00"
generated_at: "2026-10-14T10:06:15.709956+00:00"
event_type: "other_material"
sentiment: "positive"
materiality_score: 0.7
calibrated_materiality_score: 0.7
confidence: "high"
source: SEC EDGAR
---

# Biomea BMF-650 Phase 1: 1.5-3.2% weight loss in Cohorts 1-4 vs 0.1% placebo; Cohort 5 6.1% confounded

## Summary
- Mean Day 29 weight reduction 1.5% to 3.2% across MAD Cohorts 1-4 (200 mg+ QD) vs 0.1% pooled placebo; weekly loss ~0.97 kg at 200 mg or higher.
- Cohort 5 (200 mg x1 wk then 400 mg x3 wks) showed 6.1% (6.2 kg) mean weight loss at Day 29 but confinement cut placebo food intake to ~33%; results interpreted separately.
- Safety: across 5 active MAD cohorts (n=40) all TEAEs mild/moderate; no severe/serious TEAEs, no dose modifications or discontinuations; no ALT/AST increases.
- Cohort 5 GI events: nausea and vomiting each 12.5%, constipation 25%, diarrhea 0%; all Grade 1. Across all active cohorts: nausea 17.5%, vomiting 7.5%, constipation 10%, diarrhea 5%.
- BMF-650 needs longer-term toxicology studies; Biomea seeks strategic partnership/licensing; primary focus remains icovamenib in type 1 and type 2 diabetes.

## SEC filing metadata
- accession: 0001193125-26-420684
- form_type: 8-K
- ticker: BMEA
- cik: 0001840439
- company_name: Biomea Fusion, Inc.
- filed_at: 2026-10-13T21:35:08+00:00
- event_type: other_material
- sentiment: positive
- materiality_score: 0.7
- calibrated_materiality_score: 0.7
- confidence: high
- sec_items: 7.01, 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1840439/000119312526420684/0001193125-26-420684-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1840439/000119312526420684/d158362d8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001193125-26-420684
- JSON: https://secwatch.observer/filing/0001193125-26-420684.json
- Plain text: https://secwatch.observer/filing/0001193125-26-420684.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.